Como instalar TP-Link UE300 no Kubuntu:

sudo ip l s dev enxd46e0e169782 up

ou

sudo ip l s dev enp6s0 up

em:

 sudo gedit /etc/netplan/01-network-manager-all.yaml &

cole, com adaptações o seguinte:

network:

  version: 2

  renderer: NetworkManager

  ethernets:

    enxd46e0e169782:

      match:

        macaddress: "11:22:33:44:55:66"

      set-name: enp6s0

      dhcp4: true

      dhcp-identifier: mac

      critical: true

      nameservers:

         addresses: ["192.168.0.1"]

sudo netplan --debug generate

sudo netplan apply